this is the big day-long event from the WI .NET Users Group. you'll want to sign up early because it's likely to be booked full (based on last year's attendance). not to mention the badass speaker/topic list :
Scott Hanselman -- Anatomy of a Successful ASP.NET Application: Inside DasBlog
Julia Lerman -- ADO.NET 2.0 Integration with SQL Server 2005
Bill Hatfield -- AJAX and Atlas
Jason Beres -- Using WPF to Create Compelling User Interfaces
more details here, and the signup page is here. did i mention it's FREE with a smack load of prizes :) serious, you need to sign up now.